What about antibiotics?

Antimicrobial resistance

Key facts

Antibiotic resistance occurs naturally, but misuse of antibiotics in humans and animals is accelerating the process.
Antibiotic resistance is one of the biggest threats to:

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  • Global health
  • Food security
  • Advancing modern medicine
  • It can affect anyone, of any age, in any country
  • Numerous cases of antimicrobial resistance in humans have been traced to resistant microbes suspected of originating in livestock
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  • Resistant microorganisms are a major concern because a resistant infection may kill, can spread to others, and imposes huge costs to individuals and society

  • Resistant microbes are more difficult to treat, requiring alternative medications or higher doses of antimicrobials. These approaches may be more expensive, less well tolerated or even both

Antimicrobials in UTIs

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  • In the case of UTIs, only a few antibiotics are indicated
  • Resistance rates, lack of efficacy and potential side effects further limit the antibiotic armamentarium
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  • Resistance complicates future UTI treatment and increases the disease burden in the community setting
  • Continuous antibiotic prophylaxis of UTIs may increase the emergence of resistant uropathogens

Antibiotic use for rUTIs needs to be considered carefully and appropriately; it should be prevented in order to spare antimicrobials for future generations, always consult your doctor before any antibiotic intake. RECAP

Antimicrobials and microbiota

Until recently it was thought that a healthy urinary tract is sterile, however studies have shown that commensal ‘good’ bacteria such as Lactobacillus, Prevotella and Gardnerella can all be isolated in urine.

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  • Antibiotics may cause disturbances in the healthy microbiota thus affecting its natural balance
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  • Without the beneficial microbiota, the urogenital tract may be changed into a dysbiotic, sensitised state, at increased risk of colonisation by uropathogens

Antimicrobial stewardship

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  • Antimicrobial stewardship is a coordinated program that promotes the appropriate use of antimicrobials, aimed at reducing resistance and the spreading of multidrug resistant bacteria, improving patient outcomes, and sparing antibiotics themselves
  • Therefore, antibiotic consumption should be limited, controlled and responsible
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  • Increasing antimicrobial resistance, lack of therapeutic efficacy and side effects has raised the need for non-antimicrobial prophylaxis for recurrent cystitis RECAP

Inappropriate prescription / consumption of antibiotics should be discouraged.

Antibiotic sparing can help combat rising antibiotic resistance.

Stepwise prophylactic strategies may reduce antibiotic resistance

Talk about cystitis prevention with your doctor!

References

RECAP = Where a claim is followed by the RECAP, this means that this claim is endorsed by the RECAP board of experts.

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The RECAP board is a panel of international experts in urological infections. The opinions presented within this educational material are those of the RECAP board and not those of OM Pharma. Members of the RECAP board include: Jose Tiran Saucedo (Mexico), Yvette León (Mexico), Gernot Bonkat (Switzerland), Kurt G. Naber (Germany), Florian ME. Wagenlehner (Germany), J C. Nickel (Canada), Flavia Rossi (Brazil), Enrique Ubertazzi (Argentina), Agnaldo L. da Silva Filho (Brazil), Tamara S. Perepanova (Russia), Bela Köves (Hungary) & Tommaso Cai (Italy).

Patient version : MED-HQ-UV-2100071 / HCP version : MED-HQ-UV-2100070
Date of preparation: December 2021